张慧君

擅长： 肺癌、肺结节，食管癌、纵膈肿瘤，气胸，手汗症等诊断与微创手术治疗，精通中晚期肺癌，食管癌等胸部肿瘤的靶向及免疫治疗等综合治疗

简介： 张慧君，男，副主任医师 复旦大学临床医学博士 2019年于美国匹兹堡大学临床医学中心（Presbyterian医院、Shadyside医院）胸心外科进修学习。 2007-2014年在上海市肺科医院工作 2017年国家自然科学青年基金项目获得者，同时参与多项国家自然基金及上海市科委课题 中国肺康复协会委员 上海市中西医结合学会委员。 参编著作《单操作孔胸腔镜肺叶肺段切除术图谱》复旦大学出版社等著作 专业方向：肺癌、食管癌，纵膈肿瘤，肺大泡，手汗症等疾病的诊断及微创外科治疗。擅长肺部磨玻璃样结节的微创治疗（精准解剖性肺段切除）、剑突下胸腔镜胸腺肿瘤/前纵膈肿瘤切除术、胸腹腔镜食管癌切除术等手术。精通晚期胸部恶性肿瘤靶向治疗及免疫治疗等综合治疗方法 目前累计胸部手术量数千台 目前发表学术论文数十篇，以第一作者及通讯作者发表英文论文12篇 第一作者及通讯作者发表的外文学术文章： 1.CT-guided hook-wire localization of malignant pulmonary nodules for video assisted thoracoscopic surgery.J Cardiothorac Surg. 2020;15(1):307. 2.Preparation, biosafety and cytotoxicity studies of a newly tumor-microenvironment-responsive biodegradable mesoporous silicon nano-system based on multi-modal and synergistic treatment. Oxid Med Cell Longev. 2020;2020:7152173. 3. Down Regulation of SIRT2 Reduced ASS Induced NSCLC Apoptosis Through the Release of Autophagy Components via Exosomes. Front Cell Dev Biol. 2020; 8:601953.Giant mediastinal liposarcoma resected by 4. Giant mediastinal liposarcoma resected by Median sternotomy: a case report. Translational Cancer Research.2020.9(10) :6522-6527. 5. NCBP1 promotes the development of lung adenocarcinoma through up-regulation of CUL4B. J Cell Mol Med. 2019,23(10):6965-6977. 6. A case of chemorefractory metastatic type AB thymoma sensitive to helical tomotherapy . Ann Transl Med. 2019,7(12):274. 7. Thymosin beta 4 silencing suppresses proliferation and invasion of non-small cell lung cancer cells by repressing Notch1 activation. Acta Biochim Biophys Sin (Shanghai). 2016, 48(9):788-94. 8. Co-delivery of cisplatin and paclitaxel by folic acid conjugated amphiphilic PEG-PLGA copolymer nanoparticles for the treatment of non-small lung cancer.Oncotarget, 2015, 6(39):42150-42168. 9.MiR-138 inhibits tumor growth through repression of EZH2 in non-small cell lung cancer.Cellular Physiology and Biochemistry, 2013, 31(1):56-65. 10. Resveratrol inhibits TGF-β1-induced epithelial-to-mesenchymal transition and suppresses lung cancer invasion and metastasis, Toxicology, 2013, 303:139-146. 11. Transforming growth factor-beta1 induces epithelial-to-mesenchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways., Molecular Biology Reports, 2012, 39(4):3549-3556. 12.Transforming growth factor-β1 promotes lung adenocarcinoma invasion and metastasis by epithelial-to-mesenchymal transition., Mol Cell Biochem, 2011, 355(1-2):309-3.

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